Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer.
basic_science · Level V
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Abstract
The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfection of antisense thymosin beta 15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Thymosin beta 15 levels are elevated in human prostate cancer and correlate positively with the Gleason tumor grade. Thymosin beta 15 may represent a potential new biochemical marker for human prostate cancer progression.
Medical subject headings
- Carcinoma
- Cell Movement
- Gene Expression Regulation, Neoplastic
- Prostatic Neoplasms
- Thymosin