Epidermal remodelling in psoriasis.
basic_science · Level V
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- Record sourced from PubMed, PMID 8949439.
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Abstract
Psoriatic hyperproliferative epidermis is characterized by a regular elongation of rete ridges, accompanied by altered keratinization. Another notable finding is close positioning of the vasculature to the suprapapillary epidermis. These architectural/morphological changes are naturally described by a concept of epidermal remodelling based on decreased epidermal turnover time. The recently described positioning of stem cells to the tips of dermal papillae fits nicely with this concept.
Medical subject headings
- Epidermis
- Models, Biological
- Psoriasis