Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 8953039.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.
Medical subject headings
- Bone Development
- Cyclic GMP-Dependent Protein Kinases
- Dwarfism
- Intestinal Mucosa