Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain.
basic_science · Level V
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Abstract
The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains. Direct association of the Src tyrosine kinase with cloned hKv1.5 and native hKv1.5 in human myocardium was observed. This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src. Furthermore, hKv1.5 was tyrosine phosphorylated, and the channel current was suppressed, in cells coexpressing v-Src. These results provide direct biochemical evidence for a signaling complex composed of a potassium channel and a protein tyrosine kinase.
Medical subject headings
- Potassium Channels
- Potassium Channels, Voltage-Gated
- src Homology Domains
- src-Family Kinases