Levodopa therapy improves motor function in HIV-infected children with extrapyramidal syndromes.

Mintz, M; Tardieu, M; Hoyt, L; McSherry, G; Mendelson, J; Oleske, J · Neurology · 1996

case_series · Level IV

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Abstract

Five children with human immunodeficiency virus type-1 (HIV-1) infection, aged 4 to 13 years, manifested extrapyramidal dysfunction characterized by rigidity/stiffness, ambulation difficulties/shuffling gait, dysarthria/drooling/swallowing dysfunction, hypomimetic/inexpressive facies, and bradykinesia. Levodopa therapy caused an initial improvement in all symptoms, and the effect was sustained in most patients. Levodopa is a useful adjunctive therapy in HIV-1-infected children with extrapyramidal syndromes, by enhancing motor function and improving their quality of life.

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