Conserved circadian elements in phylogenetically diverse algae.
basic_science · Level V
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- Record sourced from PubMed, PMID 8962063.
- Also identified by PMC identifier 26144.
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Abstract
Circadian expression of the luciferin-binding protein (LBP) from the dinoflagellate Gonyaulax polyedra is regulated at the translational level. A small interval in the lbp 3'-untranslated region, which contains seven UG-repeats, serves as a cis-acting element to which a trans-acting factor (CCTR) binds in a circadian manner. Its binding activity correlates negatively with the circadian expression of LBP. Here I report the identification of a protein in the green alga Chlamydomonas reinhardtii that represents a CCTR analog. It binds both specifically and under control of the circadian clock to the UG-repeat region. The data show for the first time that circadian cis-elements implicated in translational regulation have been conserved during evolution.
Medical subject headings
- Chlamydomonas reinhardtii
- RNA-Binding Proteins