Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide.
basic_science · Level V
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- Record sourced from PubMed, PMID 8962118.
- Also identified by PMC identifier 26199.
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Abstract
A cytotoxic T lymphocyte (CTL) clone generated in vitro from the peripheral blood of a healthy HLA-A2-positive individual against a synthetic p53 protein-derived wild-type peptide (L9V) was shown to kill squamous carcinoma cell lines derived from two head and neck carcinomas, which expressed mutant p53 genes, in a L9V/HLA-A2 specific and restricted fashion. Thus, the normal tolerance against endogenously processed p53 protein-derived self-epitopes can be broken by peptide-specific in vitro priming. p53 protein-derived wild-type peptides might thus represent tumor associated target molecules for immunotherapeutical approaches.
Medical subject headings
- Carcinoma, Squamous Cell
- Cytotoxicity, Immunologic
- Head and Neck Neoplasms
- T-Lymphocytes, Cytotoxic
- Tumor Suppressor Protein p53