The microscopic pathology of Peyronie's disease.

Abstract

All cases of Peyronie's disease in the files were reviewed to determine the chief microscopic findings and also to note the anatomical site of the disease process. The microscopic findings in 19 cases were evaluated using hematoxylin and eosin sections, and Masson trichrome was frequently used to highlight alterations of collagen structure. Movat elastic stain and fibrinogen immunostain for fibrin were used in some cases. A perivascular lymphocytic infiltrate was found in 6 of the 19 cases, located either within the tunica albuginea or on either side of it. A linear band of ossification was found in the tunica in 5 cases. Disorganization of the collagen of the tunica was present in all cases, usually associated with a slight increase in cellularity. In 3 of 10 cases fibrin was demonstrated in the affected area of the tunica. Peyronie's disease is characterized by an alteration in the appearance and cellularity of the collagen that comprises the tunica albuginea. Ossification in the middle or inner aspect of the tunica may occur, and a perivascular lymphocytic infiltrate may or may not be present within the tunica or on either side of it.