Defective growth hormone secretion in children with pycnodysostosis and improved linear growth after growth hormone treatment.
case_series · Level IV
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- Record sourced from PubMed, PMID 8976667.
- Also identified by PMC identifier 1511688.
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Abstract
Short stature is a characteristic feature of pycnodysostosis. We report defective growth hormone secretion in response to provocation and low insulin-like growth factor-I (IGF-I) concentration in five out of six patients with pycnodysostosis. Physiological replacement with growth hormone increased IGF-I concentration and improved linear growth in these children.
Medical subject headings
- Bone Diseases, Developmental
- Growth Disorders
- Growth Hormone