Photo-induced toxic epidermal necrolysis caused by clobazam.
case_report · Level V
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- Record sourced from PubMed, PMID 8977728.
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Abstract
Toxic epidermal necrolysis (TEN) is a life-threatening disease, the pathogenesis of which remains largely unknown. We describe a 23-year-old woman under treatment with clobazam who developed lesions of TEN in light-exposed areas. Patch and photopatch tests with clobazam were negative. The cellular phenotype and cytokines were studied in blister fluid. The cellular infiltrate was composed mainly of T lymphocytes with a predominant cytotoxic phenotype. There was an increase in the level of tumour necrosis factor (TNF)-alpha in blister fluid compared with the control (a patient with bullous pemphigoid).
Medical subject headings
- Alopecia Areata
- Anti-Anxiety Agents
- Benzodiazepines
- Benzodiazepinones
- Photosensitivity Disorders
- Stevens-Johnson Syndrome