Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 8983673.
- Also identified by PMC identifier 484538.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hyperhomocysteinaemia and Helicobacter pylori infection have recently been implicated in the pathogenesis of coronary artery disease. These two risk factors, though they seem unrelated, could be linked by a deficiency of vitamins and folate caused by chronic gastritis in H pylori infection. This nutritional defect could lead to failure of methylation by 5-methyl-tetrahydrofolic acid and thus exacerbate the accumulation of homocysteine in susceptible patients. Homocysteine is toxic to endothelial cells and results in coronary artery disease.
Medical subject headings
- Coronary Disease
- Gastritis
- Helicobacter Infections
- Helicobacter pylori
- Homocysteine