From oligonucleotide shapes to genomic SELEX: novel biological regulatory loops.
review · Level V
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- Record sourced from PubMed, PMID 8990161.
- Also identified by PMC identifier 19236.
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Abstract
The SELEX method and oligonucleotide combinatorial chemistry discovery process yields high-affinity/high-specificity ligands for virtually any molecular target. Typically, the enormous starting libraries used in the SELEX process contain 10(14)-10(15) sequences. We now ask if the smaller sequences, complexity of extant organisms, and evolutionary history provide useful interactions between oligonucleotides and at least some unexpected targets. That is, do organisms contain a robust "linkage map" between their oligonucleotides and proteins and/or small molecules that enriches life?
Medical subject headings
- DNA-Directed DNA Polymerase
- Evolution, Molecular
- Gene Expression Regulation
- Molecular Biology
- Nucleic Acid Conformation
- Oligoribonucleotides
- RNA