Two-state models of protein folding kinetics.
basic_science · Level V
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- Record sourced from PubMed, PMID 8990176.
- Also identified by PMC identifier 19262.
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Abstract
The folding of some proteins appears to be a two-state kinetic process. A two-state kinetic model is justified if protein molecules rapidly equilibrate between different unfolded conformations prior to complete folding. Here I show that this rapid equilibration is a natural consequence of reasonable assumptions about reaction rate constants and folding thermodynamics.
Medical subject headings
- Models, Chemical
- Protein Folding