Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases.
basic_science · Level V
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Abstract
The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.
Medical subject headings
- Calcium-Calmodulin-Dependent Protein Kinases
- Mitogen-Activated Protein Kinases
- Proto-Oncogene Proteins c-jun
- Ubiquitins