Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics.
review · Level V
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Abstract
beta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years the number and variety of new beta-lactamases detected has risen at an alarming rate, apparently in response to the clinical use of novel classes of beta-lactam antibiotics. This paper reviews the structure and evolution of beta-lactamases in an attempt to understand the pressures that have contributed to their emergence.
Medical subject headings
- Anti-Bacterial Agents
- beta-Lactam Resistance
- beta-Lactamases