Analysis of the candidate gene NRAMP1 in the first 61 ARC National Repository families for rheumatoid arthritis.
case_control · Level III
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- Record sourced from PubMed, PMID 9002042.
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Abstract
Maximum likelihood identity-by-descent (IBD) sib pair analysis using a 3 locus haplotype NRAMP1-IL8RB-VIL1, or NRAMP1 alone, provided preliminary evidence (maximum LOD score = 1.01, p = 0.024) for a gene in this region of human chromosome 2q35 contributing to susceptibility to rheumatoid arthritis (RA). Candidacy for NRAMP1 as the disease susceptibility gene was supported by a significant bias (p < 0.048) toward transmission of the NRAMP1 promoter region allele 3 in affected offspring.
Medical subject headings
- Arthritis, Rheumatoid
- Carrier Proteins
- Cation Transport Proteins
- Membrane Proteins