Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene.
review · Level V
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Abstract
The regulation of VEGF production is mediated by both transcriptional and post-transcriptional mechanisms. A schematic model of elements involved in hypoxic regulation of VEGF is shown in Figure 1.
Medical subject headings
- Cell Hypoxia
- Endothelial Growth Factors
- Genes, Tumor Suppressor
- Ligases
- Lymphokines
- Transcription Factors
- Tumor Suppressor Proteins
- Ubiquitin-Protein Ligases
- von Hippel-Lindau Disease