Prolonged extreme thrombocytosis associated with neurofibromatosis type 1.
case_report · Level V
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- Record sourced from PubMed, PMID 9042140.
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Abstract
A girl with neurofibromatosis type 1 showed in infancy extreme thrombocytosis with platelet counts exceeding 2000 x 10(9)/L. Platelet counts remained elevated the first 4 years of life. A large deletion located at chromosome 17q11 was observed. The transient thrombocythemia may relate to a regulator of megakaryocytopoiesis located in the vicinity of the NF1 gene or to the excessive risk of chronic myelomonocytic leukemia in neurofibromatosis.
Medical subject headings
- Neurofibromatosis 1
- Thrombocytosis