Oxidative thymine dimer repair in the DNA helix.
basic_science · Level V
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- Record sourced from PubMed, PMID 9045609.
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Abstract
The metallointercalator Rh(phi)2DMB3+ (phi, 9,10-phenanthrenequinone diimine; DMB, 4,4'-dimethyl-2,2'-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-base pair DNA duplex by means of visible light. This repair could be accomplished with rhodium noncovalently bound to the duplex and at long range (16 to 26 angstroms), with the rhodium intercalator tethered to either end of the duplex assembly. This long-range repair was mediated by the DNA helix. Repair efficiency did not decrease with increasing distance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the intervening pi-stack.
Medical subject headings
- DNA
- DNA Repair
- Intercalating Agents
- Nucleic Acid Conformation
- Organometallic Compounds
- Pyrimidine Dimers
- Rhodium