RNA polymerase beta' subunit: a target of DNA binding-independent activation.
basic_science · Level V
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Abstract
The bacteriophage N4 single-stranded DNA binding protein (N4SSB) activates transcription by the Escherichia coli final sigma70-RNA polymerase at N4 late promoters. Here it is shown that the single-stranded DNA binding activity of N4SSB is not required for transcriptional activation. N4SSB interacts with the carboxyl terminus of the RNA polymerase beta' subunit in a region that is highly conserved in the largest subunits of prokaryotic and eukaryotic RNA polymerases.
Medical subject headings
- DNA, Single-Stranded
- DNA-Binding Proteins
- DNA-Directed RNA Polymerases
- Sigma Factor
- Transcription, Genetic
- Transcriptional Activation