Survey of sinonasal inverted papillomata for Epstein-Barr virus.
case_series · Level IV
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- Record sourced from PubMed, PMID 9059866.
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Abstract
Several studies have indicated an etiologic role for viruses in the development of sinonasal inverted papillomata (IP). A recent report demonstrates a strong relationship (65%) between Epstein-Barr virus (EBV) and these lesions using polymerase chain reaction (PCR) analysis. The present study analyzes a series of paraffin-embedded tissues, comprising 25 surgically resected IPs and four fungiform papillomata (FP) for the presence of EBV using a sensitive in situ hybridization (ISH) assay and PCR. None of the specimens examined showed evidence of EBV infection by ISH, and only two papillomata (one sinonasal IP and one FP) gave positive reactions for EBV using PCR. These data challenge the previous report and suggest that EBV is not a significant etiopathologic factor to be considered in the development of sinonasal IP.
Medical subject headings
- Herpesviridae Infections
- Herpesvirus 4, Human
- Nose Neoplasms
- Papilloma
- Tumor Virus Infections