Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 9092480.
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Abstract
Activation of CD4(+) T lymphocytes from human immunodeficiency virus-type 1 (HIV-1)-infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-1. Transcripts encoding CXCR4/Fusin, the fusion cofactor used by T cell line-tropic isolates, were abundant in CD3/CD28-stimulated cells, but transcripts encoding CCR5, the fusion cofactor used by macrophage-tropic viruses, were not detectable. Thus, CD3/CD28 costimulation induces an HIV-1-resistant phenotype similar to that seen in some highly exposed and HIV-uninfected individuals.
Medical subject headings
- CD28 Antigens
- CD4-Positive T-Lymphocytes
- HIV-1
- Lymphocyte Activation
- Membrane Proteins
- Receptors, HIV