Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice.
basic_science · Level V
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- Record sourced from PubMed, PMID 9096402.
- Also identified by PMC identifier 20378.
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Abstract
Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in alphaCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.
Medical subject headings
- Aging
- Calcium-Calmodulin-Dependent Protein Kinases
- Cerebral Cortex
- Neuronal Plasticity