Etretinate may work where acitretin fails.

Bleiker, T O; Bourke, J F; Graham-Brown, R A; Hutchinson, P E · Br J Dermatol · 1997

case_report · Level V

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Abstract

Acitretin (Ro 10-1670, Neotigason), a second-generation monoaromatic retinoid, is the main acid derivative and active metabolite of etretinate (Ro 10-9359, Tigason). Three patients who were unresponsive to treatment with acitretin but who responded to etretinate are reported. Twenty-nine patients in the U.K. are currently receiving etretinate on a named-patient basis. Possible explanations for the functional discrepancy between the two drugs are discussed.

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