Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.
basic_science · Level V
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- Record sourced from PubMed, PMID 9118218.
- Also identified by PMC identifier 3061830.
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Abstract
Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors.
Medical subject headings
- Glycoproteins
- Mitogens
- Proteins
- Proto-Oncogene Proteins
- Xenopus
- Zebrafish Proteins