A mouse model of Borrelia meningitis after intradermal injection.
basic_science · Level V
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Abstract
Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at approximately 25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.
Medical subject headings
- Borrelia
- Borrelia Infections
- Brain
- Meningitis, Bacterial
- Meningoencephalitis