The role of cell migration and microchimerism in the induction of tolerance after solid organ transplantation.
review · Level V
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- Record sourced from PubMed, PMID 9135829.
- Also identified by PMC identifier 2431236.
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Abstract
A new hypothesis has been proposed which states that microchimerism is the basis for the clinical tolerance seen in long-term survivors of solid organ transplants. Efforts to enhance microchimerism include simultaneous infusion of bone marrow of donor origin and transplantation of a solid organ. Studies are in progress to verify the phenomenon of microchimerism and its role in clinical tolerance.
Medical subject headings
- Bone Marrow Transplantation
- Chimera
- Immune Tolerance
- Organ Transplantation
- Transplantation Immunology