Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.
basic_science · Level V
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Abstract
Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.
Medical subject headings
- Gene Expression Regulation
- Histone Deacetylases
- Nuclear Proteins
- Repressor Proteins
- Saccharomyces cerevisiae Proteins
- Transcription Factors