Effect of phosphate concentration in buffered irrigating solutions on arterial thrombosis.
basic_science · Level V
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Abstract
The concentration of phosphate in buffered saline irrigation solutions was evaluated for its effect upon the incidence of arterial thrombosis. A rabbit thrombosis model of combined intimal abrasion and twisted pedicle in the rabbit central ear artery was used. Higher concentrations of phosphate (20 mM) in normal saline yielded a lower thrombosis rate at 7 days postoperatively (50%) in comparison to 5 mM phosphate (89% thrombosis rate; P < 0.05). A standard phosphate-buffered salt solution (Dulbecco's; 9.5 mM phosphate with potassium, calcium, and magnesium salts) also had a high thrombosis rate (91%). This study demonstrates that subtle variations in the irrigation solution can have profound effects upon arterial thrombosis.
Medical subject headings
- Buffers
- Microsurgery
- Phosphates
- Therapeutic Irrigation
- Thrombosis