A beneficial effect of oxandrolone in the treatment of Duchenne muscular dystrophy: a pilot study.
case_series · Level IV
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- Record sourced from PubMed, PMID 9153447.
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Abstract
We treated 10 boys with Duchenne muscular dystrophy with oxandrolone, an anabolic steroid, for 3 months. The mean of the changes in the average muscle score was an improvement of 0.315 +/- 0.097. The expected mean change in muscle score after 3 months from natural history data is a loss of 0.1. The difference of 0.415 between the actual and expected values is significant at p < 0.01. This preliminary evidence suggests that oxandrolone treatment may provide a degree of functional benefit for children with Duchenne muscular dystrophy that is similar to that after prednisone administration.
Medical subject headings
- Anabolic Agents
- Muscular Dystrophies
- Oxandrolone