Sustained normotension in hypertensive patients withdrawn from medication for 1 year.
prospective_cohort · Level II
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Abstract
BACKGROUND AND OBJECTIVES: Prior research indicates that up to 5% of hypertensive subjects can be successfully withdrawn from antihypertensive medications. This study determined if, in a family practice setting, greater than 5% of patients with mild essential hypertension could be withdrawn from their antihypertensive medication for more than 1 year and remain normotensive. METHODS: We enrolled 116 randomly chosen volunteer patients. Of these, 96% were white, and 58% were female. The mean age was 57, and the mean history of hypertension was 10.1 years. RESULTS: A total of 81 subjects completed the study; 46.9% of those 81 remained normotensive for 1 year after stopping medication. Females tended to do better than males at withdrawing from antihypertensives (58% versus 33%). CONCLUSIONS: The proportion of patients who successfully withdrew from antihypertensive medication for 1 year and remained normotensive was significantly greater than expected. Further studies are needed to identify factors that predict which patients will remain normotensive without medication.