Changes in extracellular brain ascorbate in rat striatum in response to administration of non-volatile anaesthetic agents.
basic_science · Level V
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Abstract
We used constant potential in vivo voltammetry to measure changes in striatal ascorbate in the rat in response to i.p. administration of several non-volatile anaesthetics. Propofol and pentobarbitone, which enhance GABA-mediated neuronal inhibitions, decreased ascorbate current to 27.0 (SEM 7.4) % and 46 (6) % of control, respectively. Chloral hydrate, diazepam alone or with ketamine, and fentanyl-fluanisone with midazolam produced no changes in ascorbate current.
Medical subject headings
- Anesthetics, Intravenous
- Ascorbic Acid
- Corpus Striatum