A paradoxical effect of bronchodilators.

Maury, E; Ioos, V; Lepecq, B; Guidet, B; Offenstadt, G · Chest · 1997

case_report · Level V

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Abstract

Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.

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