Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry.
basic_science · Level V
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Abstract
The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.
Medical subject headings
- Cytomegalovirus
- HIV-1
- HIV-2
- Receptors, Chemokine
- Receptors, Cytokine
- Receptors, HIV
- Viral Proteins