Squamous cell carcinoma in perineal inflammatory disease.
case_series · Level IV
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Abstract
Four patients with squamous cell carcinoma of the perineal region were diagnosed and treated during the last 4 years in our institutions. The underlying diagnoses consisted of recurrent pilonidal disease, Crohn's disease, and hidradenitis suppurativa. In all patients, a pattern of a long-term inflammatory process was evident. Current concepts regarding the pathophysiology of a chronic inflammatory state and malignant transformation are reviewed. We conclude that regardless of the original pathology, all chronic inflammatory processes in the perineal region should be evaluated for malignant degeneration. A high index of suspicion may potentiate an early diagnosis, possibly improving the chance of cure.
Medical subject headings
- Abscess
- Carcinoma, Squamous Cell
- Perineum
- Pilonidal Sinus
- Skin Diseases, Infectious
- Skin Neoplasms