Double identity for proteins of the Bcl-2 family.
basic_science · Level V
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- Record sourced from PubMed, PMID 9194558.
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Abstract
Bcl-2 is an oncogenic protein that acts by inhibiting programmed cell death. The mechanisms used by this and related anti-apoptotic proteins to protect cells from cytotoxic stimuli are now emerging, with the discovery that Bcl-2 can function both as an ion channel and as an adaptor or docking protein.
Medical subject headings
- Apoptosis
- Caenorhabditis elegans Proteins
- Calcium-Binding Proteins
- Helminth Proteins
- Ion Channels
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2