In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound.
basic_science · Level V
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Abstract
Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.
Medical subject headings
- Contrast Media
- Drug Delivery Systems
- Image Enhancement
- Magnetic Resonance Imaging
- Meglumine
- Organometallic Compounds
- Pentetic Acid
- Ultrasonic Therapy
- Ultrasonography, Doppler, Pulsed