Granulosa cell tumor of the ovary associated with antecedent tamoxifen use.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 9205462.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Increased attention has been focused recently on the estrogenic effects of tamoxifen. Review of the literature reveals an association between tamoxifen use and gynecologic tumors. A 52-year-old postmenopausal woman was treated with tamoxifen for stage II estrogen receptor-positive breast carcinoma. Her aspartate transaminase and alanine transaminase levels increase markedly after 6 months of tamoxifen use. After an additional 17 months of elevated serum transaminases, the patient was found to have a stage Ic granulosa cell tumor of the ovary. Patients with tamoxifen-induced liver dysfunction may be at increased risk for granulosa cell tumors because of alterations in tamoxifen metabolism.
Medical subject headings
- Antineoplastic Agents, Hormonal
- Breast Neoplasms
- Granulosa Cell Tumor
- Neoplasms, Second Primary
- Ovarian Neoplasms
- Tamoxifen