BRCA1 is a cell cycle-regulated nuclear phosphoprotein.
basic_science · Level V
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- Record sourced from PubMed, PMID 9207057.
- Also identified by PMC identifier 23770.
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Abstract
We have characterized the BRCA1 gene product by using four polyclonal antibodies raised against peptides from four different regions of the protein. The antibodies specifically recognize an approximately 220-kDa BRCA1 protein that is predominantly expressed in the nucleus of both normal and neoplastic breast cancer cells. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. We propose that BRCA1 is a phosphoprotein that alters in a qualitative and quantitative manner during cell cycle progression.
Medical subject headings
- BRCA1 Protein
- Cell Cycle Proteins
- Nuclear Proteins
- Phosphoproteins