Minocycline and ethylenediaminetetraacetate for the prevention of recurrent vascular catheter infections.
case_report · Level V
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- Record sourced from PubMed, PMID 9243049.
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Abstract
Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen daily with the same solution. In vitro and in vivo experiments showed that minocycline/EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.
Medical subject headings
- Anti-Bacterial Agents
- Bacteremia
- Catheterization, Central Venous
- Edetic Acid
- Enterobacteriaceae Infections
- Minocycline
- Staphylococcal Infections