Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 9252325.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The epithelium that lines the gut is impermeable to macromolecules and microorganisms, except in Peyer's patches (PPs), where the lymphoid follicle-associated epithelium (FAE) contains M cells that transport antigens and microorganisms. A cultured system that reproduces the main characteristics of FAE and M cells was established by cultivation of PP lymphocytes with the differentiated human intestinal cell line Caco-2. Lymphocytes settled into the epithelial monolayer, inducing reorganization of the brush border and a temperature-dependent transport of particles and Vibrio cholerae. This model system could prove useful for intestinal physiology, vaccine research, and drug delivery studies.
Medical subject headings
- Bacterial Translocation
- Immunity, Mucosal
- Intestinal Mucosa
- Lymphocytes
- Peyer's Patches
- Vibrio cholerae