Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 9255207.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We examined T-cell proliferation in five patients with X-linked hyper-IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.
Medical subject headings
- Antigens
- Genetic Linkage
- Hypergammaglobulinemia
- Immunoglobulin M
- Immunologic Deficiency Syndromes
- Lymphocyte Activation
- T-Lymphocytes
- X Chromosome