An ulcerated lesion at the BCG vaccination site during the course of Kawasaki disease.
case_report · Level V
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- Record sourced from PubMed, PMID 9270532.
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Abstract
We describe a bacillus Calmette-Guérin (BCG) granuloma that occurred during the course of Kawasaki disease. A 12-month-old male infant with Kawasaki disease had an erythematous indurated plaque with prominent necrotic ulceration at the BCG vaccination site on the left upper arm. Histologic study showed a granulomatous reaction consisting of epithelioid histiocytes, lymphoid cells, and Langhans-type giant cells. No evidence of mycobacterial infection was obtained. The lesion healed completely within 2 weeks without administration of antituberculous agents. We believe that the granulomatous reaction occurred as a result of hypersensitivity to proteins in the BCG vaccine, which appeared after the onset of Kawasaki disease.
Medical subject headings
- Adjuvants, Immunologic
- BCG Vaccine
- Granuloma
- Mucocutaneous Lymph Node Syndrome
- Skin Ulcer