Ibuprofen release from hydrophilic ceramic-polymer composites.

Abstract

Two composite systems composed of alpha-Al2O3/poly(methyl methacrylate) (PMMA)/poly(vinyl pyrrolidone) (PVP)/ibuprofen or alpha-Al2O3/PMMA/co-vinyl pyrrolidone-methyl methacrylate/ibuprofen were prepared by free radical polymerization. These systems were characterized by spectroscopic techniques and thermogravimetric and differential thermal analyses. The hydration behaviour of composites with different hydrophilic characters was analysed after the immersion of the composites in buffered solution at pH 7.4 and 37 degrees C. The swelling of the composites depends strongly on the content of the hydrophilic component and is controlled by the presence of the ceramic component. The release of the anti-inflammatory drug, ibuprofen, from the composites in buffered solution was followed by UV spectroscopy and the results obtained indicated that the components of the composites influenced the rate of release of the drug, without the classical 'burst' effect observed frequently with hydrophilic systems.