Immunoablation does not delay the neurologic progression of X-linked adrenoleukodystrophy.
case_report · Level V
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Abstract
We report the results of a near total myeloablation in preparation for bone marrow transplantation in a boy with minimal symptoms of X-linked adrenoleukodystrophy. Severe cerebral X-linked adrenoleukodystrophy developed in the patient after failure of bone marrow transplantation. This experience suggests that immunotherapy alone is not responsible for the improvement observed in some patients with X-ALD after BMT.
Medical subject headings
- Bone Marrow Transplantation
- Genetic Linkage
- Peroxisomal Disorders
- Transplantation Conditioning
- X Chromosome