Calcipotriol/calcipotriene (Dovonex/Daivonex) in combination with phototherapy: a review.

Abstract

Calcipotriol/calcipotriene (Dovonex/Daivonex) ointment plus phototherapy has been used in the treatment of psoriasis. We will attempt to clarify two issues: First, is there any benefit to combining the above treatment modalities? Second, is there any increased risk associated with the use of the combination? A complete review of the literature revealed four studies dealing with the combination of calcipotriol with UVB phototherapy and three studies dealing with the combination of calcipotriol with PUVA phototherapy. These studies showed an advantage to the use of the combination compared with the use of either treatment alone. Topical calcipotriol enhances the effect of UVB and PUVA phototherapy.