A protein particle vaccine containing multiple malaria epitopes.
basic_science · Level V
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- Record sourced from PubMed, PMID 9359112.
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Abstract
Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.
Medical subject headings
- Epitopes
- Malaria Vaccines
- Plasmodium falciparum