General mechanisms of metastasis.
review · Level V
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- Record sourced from PubMed, PMID 9362419.
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Abstract
In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed.
Medical subject headings
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neovascularization, Pathologic