The potential role of hepatitis C virus in the pathogenesis of the neurological syndrome in chronic hepatitis C.
case_report · Level V
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- Record sourced from PubMed, PMID 9378402.
- Also identified by PMC identifier 1891496.
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Abstract
A 72-year-old man developed chronic sensory neuropathy (CSN) during chronic hepatitis C (HCV) infection. Neurological symptoms began one year after acute HCV hepatitis and slowly worsened over three years. No conventional cause for CSN was found. Circulating antinervous tissue antibodies (including anti-Hu) and inflammatory infiltrates in sural nerve biopsy specimens were absent. However, the presence of anti-HCV antibody and HCV-RNA in cerebrospinal fluid indicated that HCV had reached the intrathecal compartment, suggesting the direct viral involvement in the pathogenesis of CSN.
Medical subject headings
- Hepacivirus
- Hepatitis C
- Hepatitis, Chronic
- Nervous System Diseases