Effect of temperature and cardiopulmonary bypass on the pharmacokinetics of remifentanil.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 9389262.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Sixteen patients undergoing coronary revascularization requiring cardiopulmonary bypass received remifentanil 2 micrograms kg-1 or 5 micrograms kg-1 by infusion over 1 min after sternotomy but before commencing cardiopulmonary bypass, during hypothermic cardiopulmonary bypass and during cardiopulmonary bypass after rewarming. Hypothermic cardiopulmonary bypass reduced the clearance of remifentanil by an average of 20%, and this was attributed to the effect of temperature on blood and tissue esterase activity. Reductions in arterial pressure occurred with administration of both doses during normothermia only.
Medical subject headings
- Analgesics, Opioid
- Body Temperature
- Cardiopulmonary Bypass
- Piperidines